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KMID : 0352519850220010251
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Korea Univercity Medical Journal
1985 Volume.22 No. 1 p.251 ~ p.263
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A Comparative Study on the Dermal Reaction in 116 Healthy Korean Young Men to the Cytoplasmic Antigens of Mycobacterium tuberculosis, B.C.G. and 7 Species of Non-tuberculous Mycobacteria
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Abstract
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The present study was carried out to investigate the reactivity of 116 healthy young Korean Marine Corps Recruits to the cytoplasmic antigens of Mycobacterium tuberculosis, Bacillus Calmette Guerin(B.C.G.) and 7 species of non-tuberculous mycobacteria, and to access the degree of cross reactivity among the dermal reactions to the cytoplasmic antigens of 9 species of mycobacteria. The cytoplasmic antigens were prepared from M. tuberculosis, B.C. G., M. kansasii, M. marinum, M. scrofulaceum, M. fortuitum, M. phlei, M. vaccae and M. sm egmatis by passing 5 times through a French Pressure Cell Press Oat 18,000 lbs/inch² and by differential centrifugation. The antigens were injected intradermally on the forearms and the reactions were read 72 hours later.
The results were summarized as follows :
1. Among the 9 species of mycobacteria, M. tuberculosis showed the highest positive reaction rate (79.3%), followed by B.C.G. (66.4%), M. scrofulaceum (39.7%) and M. vaccae (35.3%). Other 5 species of mycobacteria Showed relatively lower positive reaction rates covering 10.3% to 19.8%.
2. Generally, 9 species of mycobacteria showed relatively high cross reactions to one another.
a) M. tuberculosis showed high cross reaction to B.C.G., M. vaccae and M. scrofulaceum, but not to the other 5 species of mycobacteria.
b) B.C.G. showed high cross reaction to all of the tested mycobacteria except M. kansasii. B.C.G. showed most significant association (p<0.005) with M. tuberculosis, M. scrofulaceum and M. vaccae.
c) M. scrofulaceum showed high cross reaction to all of 8 tested mycobacteria.
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